BDBM154576 K03861 (1)

SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1

InChI Key InChIKey=PWDLXPJQFNVTNL-UHFFFAOYSA-N

Data  9 IC50  6 Kd  4 ITC

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 154576   

TargetCyclin-dependent kinase 2 [C118L](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM154576(K03861 (1))
Affinity DataIC50:  7.20E+3nMpH: 7.5Assay Description:For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2 [C118L](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM154576(K03861 (1))
Affinity DataKd:  18.6nMpH: 7.5 T: 2°CAssay Description:All ITC experiments were performed using a VP-ITC (Microcal, Northampton, MA) instrument at 10 or 15 °C in 50 mM HEPES, pH 7.5, 300 mM NaCl, and 1 mM...More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 154576   

CellCyclin-dependent protein kinase 2 variant (CDK2 C118L)(Homo sapiens (Human))
University of Oxford

SyringePNGBDBM154576(K03861 (1))
ITC DataΔG°: -10.2kcal/mole −TΔS°: 4.75kcal/mole ΔH°: -14.9kcal/mole logk: 5.51E+7
pH: 7.5 T: 15.00°C